halophFGD

Basic Information

Locus ID: Ag7G01322

Species & Taxonomic ID: Apium graveolens & 4045

Genome Assembly: GCA_009905375.1

Short Name: HDH

Description: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

Maps and Mapping Data

Chromosome	Start	End	Strand	ID
chr7	141969497	141980468	+	Ag7G01322

Protein Data

Protein Properties:

Theoretical pI	Molecular Weight	Instability Index	Aliphatic Index	GRAVY
5.34	52,547.54 Da	40.73	93.25	0.02

Protein Domain:

Category	ID	Description	Start	End	Evalue/Score	InterPro ID
CDD	cd06572	Histidinol_dh	73	463	0.0	IPR012131
Pfam	PF00815	Histidinol dehydrogenase	65	471	2.1E-160	IPR012131
SUPERFAMILY	SSF53720	ALDH-like	71	471	9.02E-72	IPR016161
Gene3D	G3DSA:1.20.5.1300	-	430	475	1.8E-21	-
Gene3D	G3DSA:3.40.50.1980	Nitrogenase molybdenum iron protein domain	75	429	8.9E-121	-
Gene3D	G3DSA:3.40.50.1980	Nitrogenase molybdenum iron protein domain	277	395	8.9E-121	-
TIGRFAM	TIGR00069	hisD: histidinol dehydrogenase	77	470	1.1E-148	IPR012131
PIRSF	PIRSF000099	Histidinol_dh	42	474	2.0E-174	IPR022695
ProSitePatterns	PS00611	Histidinol dehydrogenase signature.	273	305	-	IPR001692
PRINTS	PR00083	Histidinol dehydrogenase signature	295	314	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	273	294	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	241	266	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	211	237	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	405	423	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	364	389	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	77	101	1.5E-98	IPR012131
PRINTS	PR00083	Histidinol dehydrogenase signature	176	202	1.5E-98	IPR012131
Hamap	MF_01024	Histidinol dehydrogenase [hisD].	46	472	63.941597	IPR012131

Gene Ontology

Biological Process:

GO:0000105 (L-histidine biosynthetic process)

Molecular Function:

GO:0004399 (histidinol dehydrogenase activity) GO:0016491 (oxidoreductase activity) GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) GO:0046872 (metal ion binding) GO:0051287 (NAD binding)

KEGG Pathway

KO Term:

K00013 (histidinol dehydrogenase [EC:1.1.1.23])

Pathway:

ko00340 (Histidine metabolism) map00340 (Histidine metabolism) ko01100 (Metabolic pathways) map01100 (Metabolic pathways) ko01110 (Biosynthesis of secondary metabolites) map01110 (Biosynthesis of secondary metabolites) ko01230 (Biosynthesis of amino acids) map01230 (Biosynthesis of amino acids)

Module:

M00026 (Histidine biosynthesis, PRPP => histidine)

Reaction:

R01158 (L-Histidinol + 2 NAD+ + H2O <=> L-Histidine + 2 NADH + 2 H+) R01163 (L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+) R03012 (L-Histidinol + NAD+ <=> L-Histidinal + NADH + H+)

Best hit

Source	Best Hit ID	Description
TAIR	AT5G63890.1	histidinol dehydrogenase. Encodes histidinol dehydrogenase. Up-regulated in response to UV-B.
RefSeq	XP_017229906.1	PREDICTED: histidinol dehydrogenase, chloroplastic [Daucus carota subsp. sativus]
Swiss-Prot	Q5NAY4	Histidinol dehydrogenase, chloroplastic OS=Oryza sativa subsp. japonica OX=39947 GN=HDH PE=2 SV=1
TrEMBL	A0A162B5R3	histidinol dehydrogenase OS=Daucus carota subsp. sativus OX=79200 GN=DCAR_003019 PE=3 SV=1

Expression

BioProject	Accession	TPM	Cultivar	Tissue	Development Stage	Sample Name	Description
PRJNA723697	SRX10692252	56.75246	Shengqin NO.2	seed	S1-1	S1-1	initial formation stage (S1)
PRJNA723697	SRX10692254	39.609711	Shengqin NO.2	seed	S1-3	S1-3	initial formation stage (S1)
PRJNA723697	SRX10692255	37.290611	Shengqin NO.2	seed	S3-1	S3-1	middle development stage (S3)
PRJNA723697	SRX10692256	36.972874	Shengqin NO.2	seed	S3-2	S3-2	middle development stage (S3)
PRJNA723697	SRX10692257	35.644688	Shengqin NO.2	seed	S3-3	S3-3	middle development stage (S3)
PRJNA723697	SRX10692258	33.899689	Shengqin NO.2	seed	S5-1	S5-1	maturation stage (S5)
PRJNA723697	SRX10692259	29.292538	Shengqin NO.2	seed	S5-2	S5-2	maturation stage (S5)
PRJNA723697	SRX10692260	18.778471	Shengqin NO.2	seed	S5-3	S5-3	maturation stage (S5)
PRJNA884666	SRX17729272	71.125145	celery	anther		W99A-r1	male sterile lineÂ
PRJNA884666	SRX17729273	66.905518	celery	anther		W99A-r2	male sterile lineÂ
PRJNA884666	SRX17729274	75.986328	celery	anther		W99A-r3	male sterile lineÂ
PRJNA884666	SRX17729275	76.861397	celery	anther		W99B-r1	maintainer line
PRJNA884666	SRX17729276	80.734222	celery	anther		W99B-r2	maintainer line
PRJNA884666	SRX17729277	70.897202	celery	anther		W99B-r3	maintainer line
PRJNA884180	SRX17743889	49.24258	var. secalinum Yablochny	collenchyma		Col_S1_rep1-1
PRJNA884180	SRX17748056	55.173176	var. secalinum Yablochny	collenchyma		Col_S1_rep3	biological replicate 3
PRJNA884180	SRX17748057	62.336338	var. secalinum Yablochny	collenchyma		Col_S1_rep4	biological replicate 4
PRJNA884180	SRX17748678	86.013611	var. secalinum Yablochny	parenchyma		Par_S1_rep1	Biological replicate 1
PRJNA884180	SRX17748679	85.297081	var. secalinum Yablochny	parenchyma		Par_S1_rep2	Biological replicate 2
PRJNA884180	SRX17748680	90.818726	var. secalinum Yablochny	parenchyma		Par_S1_rep3	Biological replicate 3
PRJNA884180	SRX17748681	102.341125	var. secalinum Yablochny	parenchyma		Par_S1_rep4	Biological replicate 4
PRJNA884180	SRX17748898	89.322243	var. secalinum Yablochny	vascular bundle		Vas_S1_rep1	Biological replicate 1
PRJNA884180	SRX17748899	91.764091	var. secalinum Yablochny	vascular bundle		Vas_S1_rep2	Biological replicate 2
PRJNA884180	SRX17748900	87.879478	var. secalinum Yablochny	vascular bundle		Vas_S1_rep3	Biological replicate 3
PRJNA884180	SRX17748901	90.823463	var. secalinum Yablochny	vascular bundle		Vas_S1_rep4	Biological replicate 4
PRJNA884180	SRX17749129	92.07412	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep1	Biological replicate 1
PRJNA884180	SRX17749130	87.866119	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep2	Biological replicate 2
PRJNA884180	SRX17749131	92.211685	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep3	Biological replicate 3
PRJNA884180	SRX17749132	88.031746	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep4	Biological replicate 4
PRJNA1124269	SRX24936411	82.839897		leaf		CK1	replicate=biological replicate1
PRJNA1124269	SRX24936412	88.71759		leaf		CK2	replicate=biological replicate2
PRJNA1124269	SRX24936413	73.975311		leaf		CK3	replicate=biological replicate3
PRJNA1124269	SRX24936414	59.033607		leaf		D1	replicate=biological replicate1
PRJNA1124269	SRX24936415	53.209843		leaf		D2	replicate=biological replicate2
PRJNA1124269	SRX24936416	56.529167		leaf		D3	replicate=biological replicate3
PRJNA1124269	SRX24936417	48.43718		leaf		MD1	replicate=biological replicate1
PRJNA1124269	SRX24936418	40.841751		leaf		MD2	replicate=biological replicate2
PRJNA1124269	SRX24936419	42.486256		leaf		MD3	replicate=biological replicate3
PRJNA387092	SRX2833309	147.477295	shanghaihuangxin	leaf	leaves between 0.5 and 1 cm in breadth, folded;	stage 2
PRJNA387092	SRX2833321	130.967682	shanghaihuangxin	leaf	leaves between 2and 2.5 cm in breadth, nearly unfolded, with clear stem exten-sion	stage 5
PRJNA387092	SRX2833323	140.586349	shanghaihuangxin	leaf	leaves >3 cm, unfolded, with clearstem extension	stage 7
PRJNA543957	SRX5879598	107.228424	Zhangzhou lvqing	stem		Se3	100 ppm Na2SeO4
PRJNA543957	SRX5879599	75.677345	Zhangzhou lvqing	stem		Se2	100 ppm Na2SeO4
PRJNA543957	SRX5879600	135.058533	Zhangzhou lvqing	stem		Mock2	mock
PRJNA543957	SRX5879601	108.190468	Zhangzhou lvqing	stem		Mock1	mock
PRJNA543957	SRX5879602	112.248901	Zhangzhou lvqing	stem		Se1	100 ppm Na2SeO4
PRJNA543957	SRX5879603	90.409203	Zhangzhou lvqing	stem		Mock3	mock
PRJNA609149	SRX7815917	82.547745	Jinnan Shiqin	flower bud	early flower bud	early flower bud
PRJNA609149	SRX7815918	80.233139	Jinnan Shiqin	flower bud	middle flower bud	middle flower bud
PRJNA609149	SRX7815919	86.019989	Jinnan Shiqin	flower bud	early flowering period	early flowering period

Network

🔍 Co-expression Network

🔍 Protein-Protein Interaction Network

Orthology

Family	Species	Count	Orthologous Genes
Acanthaceae	Avicennia marina	1	jg1489
Aizoaceae	Mesembryanthemum crystallinum	1	gene_23447
Amaranthaceae	Atriplex hortensis	1	Ah004930
Amaranthaceae	Beta vulgaris	1	BVRB_1g001220
Amaranthaceae	Salicornia bigelovii	2	Sbi_jg29463, Sbi_jg3711
Amaranthaceae	Salicornia europaea	1	Seu_jg6267
Amaranthaceae	Suaeda aralocaspica	1	GOSA_00000749
Amaranthaceae	Suaeda glauca	2	Sgl10721, Sgl16076
Amaranthaceae	Chenopodium album	3	gene:ENSEOMG00000011615, gene:ENSEOMG00000025632 ... gene:ENSEOMG00000040363
Amaranthaceae	Chenopodium quinoa	3	CQ.Regalona.r1.4AG0000830, CQ.Regalona.r1.4BG0000100 ... CQ.Regalona.r1.4BG0001000
Anacardiaceae	Pistacia vera	2	pistato.v30077100, pistato.v30077300
Apiaceae	Apium graveolens	1	Ag7G01322
Arecaceae	Cocos nucifera	1	COCNU_14G008930
Arecaceae	Phoenix dactylifera	1	gene-LOC103710491
Asparagaceae	Asparagus officinalis	2	AsparagusV1_01.3250.V1.1, AsparagusV1_07.3475.V1.1
Asteraceae	Flaveria trinervia	2	Ftri17G05373, Ftri6G33859
Brassicaceae	Arabidopsis thaliana	1	AT5G63890.2
Brassicaceae	Eutrema salsugineum	1	Thhalv10004035m.g.v1.0
Brassicaceae	Schrenkiella parvula	1	Sp2g26950.v2.2
Brassicaceae	Brassica nigra	2	BniB06g012140.2N, BniB07g042570.2N
Casuarinaceae	Casuarina equisetifolia	1	Ceq07G1974
Casuarinaceae	Casuarina glauca	3	Cgl07G2112, Cgl07G2121, Cgl07G2169
Cymodoceaceae	Cymodocea nodosa	1	gene.Cymno17g03800
Dunaliellaceae	Dunaliella salina	1	Dusal.0217s00001.v1.0
Hydrocharitaceae	Thalassia testudinum	1	gene.Thate06g06910
Nitrariaceae	Nitraria sibirica	1	evm.TU.LG12.481
Plantaginaceae	Plantago ovata	2	Pov_00014733, Pov_00037450
Plumbaginaceae	Limonium bicolor	1	Lb5G27597
Poaceae	Echinochloa crus-galli	2	AH01.123, BH03.3863
Poaceae	Eleusine coracana subsp. coracana	2	gene-QOZ80_3AG0213550, gene-QOZ80_3BG0258670
Poaceae	Hordeum vulgare	1	HORVU.MOREX.r3.2HG0165510.1
Poaceae	Lolium multiflorum	1	gene-QYE76_043713
Poaceae	Oryza coarctata	2	Oco01G005940, Oco02G006020
Poaceae	Oryza sativa	1	LOC_Os01g13190.1
Poaceae	Paspalum vaginatum	2	gene-BS78_01G058900, gene-BS78_01G219800
Poaceae	Puccinellia tenuiflora	2	Pt_Chr0302857, Pt_Chr0302926
Poaceae	Sporobolus alterniflorus	8	Chr01G003430, Chr04G030010, Chr0G012730, Chr0G020610 ... Chr0G025040, Chr0G025290, Chr12G035290, Chr12G035570
Poaceae	Thinopyrum elongatum	1	Tel2E01G519300
Poaceae	Triticum dicoccoides	2	gene_TRIDC2AG042300, gene_TRIDC2BG045390
Poaceae	Triticum aestivum	3	TraesCS2A02G292100.1, TraesCS2B02G308600.3 ... TraesCS2D02G290100.2
Poaceae	Zea mays	1	Zm00001eb059830_P005
Poaceae	Zoysia japonica	3	nbis-gene-15264, nbis-gene-15266, nbis-gene-16395
Poaceae	Zoysia macrostachya	1	Zma_g2629
Portulacaceae	Portulaca oleracea	2	evm.TU.LG04.2014, evm.TU.LG06.311
Posidoniaceae	Posidonia oceanica	1	gene.Posoc10g05480
Rhizophoraceae	Bruguiera sexangula	1	evm.TU.Scaffold_14_RagTag.990
Rhizophoraceae	Carallia pectinifolia	1	nbisL1-mrna-16835
Rhizophoraceae	Ceriops tagal	1	nbisL1-mrna-13064
Rhizophoraceae	Ceriops zippeliana	1	nbisL1-mrna-17284
Rhizophoraceae	Kandelia candel	1	evm.TU.utg000025l.142
Rhizophoraceae	Kandelia obovata	1	Maker00012275
Rhizophoraceae	Rhizophora apiculata	1	nbisL1-mrna-8619
Rhizophoraceae	Rhizophora mangle	1	nbisL1-mrna-22990
Salicaceae	Populus euphratica	2	populus_peu00070, populus_peu17142
Solanaceae	Lycium barbarum	1	gene-LOC132623324
Solanaceae	Solanum chilense	1	SOLCI003514500
Solanaceae	Solanum pennellii	1	gene-LOC107011402
Tamaricaceae	Reaumuria soongarica	2	STRG.26483_chr11_+, STRG.8703_chr06_+
Tamaricaceae	Tamarix chinensis	1	TC09G2436
Zosteraceae	Zostera marina	1	Zosma02g17900.v3.1