halophFGD

Basic Information

Locus ID: Ag2G02557

Species & Taxonomic ID: Apium graveolens & 4045

Genome Assembly: GCA_009905375.1

Description: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting

Maps and Mapping Data

Chromosome	Start	End	Strand	ID
chr2	300896735	300898093	+	Ag2G02557

Protein Data

Protein Properties:

Theoretical pI	Molecular Weight	Instability Index	Aliphatic Index	GRAVY
9.22	52,152.58 Da	50.05	76.17	-0.63

Protein Domain:

Category	ID	Description	Start	End	Evalue/Score	InterPro ID
Pfam	PF00069	Protein kinase domain	103	428	9.8E-9	IPR000719
SUPERFAMILY	SSF101447	Formin homology 2 domain (FH2 domain)	15	420	9.68E-8	-
SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	75	433	6.93E-20	IPR011009
Gene3D	G3DSA:1.10.510.10	Transferase(Phosphotransferase) domain 1	98	436	7.4E-18	-
SMART	SM00220	serkin_6	41	428	9.6E-5	IPR000719
ProSiteProfiles	PS50011	Protein kinase domain profile.	41	428	14.040023	IPR000719
MobiDBLite	mobidb-lite	consensus disorder prediction	8	28	-	-
MobiDBLite	mobidb-lite	consensus disorder prediction	1	28	-	-
Coils	Coil	Coil	304	324	-	-

Gene Ontology

Biological Process:

GO:0006468 (protein phosphorylation)

Molecular Function:

GO:0004672 (protein kinase activity) GO:0005524 (ATP binding)

KEGG Pathway

KO Term:

K01551 (arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-])

Best hit

Source	Best Hit ID	Description
RefSeq	XP_017240771.1	PREDICTED: serine/threonine-protein kinase BLUS1-like [Daucus carota subsp. sativus]
Swiss-Prot	Q7Z2Y5	Nik-related protein kinase OS=Homo sapiens OX=9606 GN=NRK PE=1 SV=2
TrEMBL	A0A166ASH1	Protein kinase domain-containing protein OS=Daucus carota subsp. sativus OX=79200 GN=DCAR_010486 PE=4 SV=1

Expression

BioProject	Accession	TPM	Cultivar	Tissue	Development Stage	Sample Name	Description
PRJNA723697	SRX10692252	0	Shengqin NO.2	seed	S1-1	S1-1	initial formation stage (S1)
PRJNA723697	SRX10692254	0.135276	Shengqin NO.2	seed	S1-3	S1-3	initial formation stage (S1)
PRJNA723697	SRX10692255	0	Shengqin NO.2	seed	S3-1	S3-1	middle development stage (S3)
PRJNA723697	SRX10692256	0	Shengqin NO.2	seed	S3-2	S3-2	middle development stage (S3)
PRJNA723697	SRX10692257	0	Shengqin NO.2	seed	S3-3	S3-3	middle development stage (S3)
PRJNA723697	SRX10692258	0	Shengqin NO.2	seed	S5-1	S5-1	maturation stage (S5)
PRJNA723697	SRX10692259	0	Shengqin NO.2	seed	S5-2	S5-2	maturation stage (S5)
PRJNA723697	SRX10692260	0	Shengqin NO.2	seed	S5-3	S5-3	maturation stage (S5)
PRJNA884666	SRX17729272	0	celery	anther		W99A-r1	male sterile lineÂ
PRJNA884666	SRX17729273	0.121022	celery	anther		W99A-r2	male sterile lineÂ
PRJNA884666	SRX17729274	0.063552	celery	anther		W99A-r3	male sterile lineÂ
PRJNA884666	SRX17729275	0.285685	celery	anther		W99B-r1	maintainer line
PRJNA884666	SRX17729276	0.730216	celery	anther		W99B-r2	maintainer line
PRJNA884666	SRX17729277	0.685107	celery	anther		W99B-r3	maintainer line
PRJNA884180	SRX17743889	0.070871	var. secalinum Yablochny	collenchyma		Col_S1_rep1-1
PRJNA884180	SRX17748056	0	var. secalinum Yablochny	collenchyma		Col_S1_rep3	biological replicate 3
PRJNA884180	SRX17748057	0	var. secalinum Yablochny	collenchyma		Col_S1_rep4	biological replicate 4
PRJNA884180	SRX17748678	0.070444	var. secalinum Yablochny	parenchyma		Par_S1_rep1	Biological replicate 1
PRJNA884180	SRX17748679	0	var. secalinum Yablochny	parenchyma		Par_S1_rep2	Biological replicate 2
PRJNA884180	SRX17748680	0.013042	var. secalinum Yablochny	parenchyma		Par_S1_rep3	Biological replicate 3
PRJNA884180	SRX17748681	0.083771	var. secalinum Yablochny	parenchyma		Par_S1_rep4	Biological replicate 4
PRJNA884180	SRX17748898	0.336207	var. secalinum Yablochny	vascular bundle		Vas_S1_rep1	Biological replicate 1
PRJNA884180	SRX17748899	1.082844	var. secalinum Yablochny	vascular bundle		Vas_S1_rep2	Biological replicate 2
PRJNA884180	SRX17748900	0.053723	var. secalinum Yablochny	vascular bundle		Vas_S1_rep3	Biological replicate 3
PRJNA884180	SRX17748901	0.274918	var. secalinum Yablochny	vascular bundle		Vas_S1_rep4	Biological replicate 4
PRJNA884180	SRX17749129	0.194643	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep1	Biological replicate 1
PRJNA884180	SRX17749130	0.11713	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep2	Biological replicate 2
PRJNA884180	SRX17749131	0.164396	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep3	Biological replicate 3
PRJNA884180	SRX17749132	0.110581	var. secalinum Yablochny	part of the celery petiole without collenchyma strands		Collenchyma-free_S1_rep4	Biological replicate 4
PRJNA1124269	SRX24936411	0		leaf		CK1	replicate=biological replicate1
PRJNA1124269	SRX24936412	0		leaf		CK2	replicate=biological replicate2
PRJNA1124269	SRX24936413	0.097722		leaf		CK3	replicate=biological replicate3
PRJNA1124269	SRX24936414	0		leaf		D1	replicate=biological replicate1
PRJNA1124269	SRX24936415	0.705067		leaf		D2	replicate=biological replicate2
PRJNA1124269	SRX24936416	0		leaf		D3	replicate=biological replicate3
PRJNA1124269	SRX24936417	0		leaf		MD1	replicate=biological replicate1
PRJNA1124269	SRX24936418	0		leaf		MD2	replicate=biological replicate2
PRJNA1124269	SRX24936419	0		leaf		MD3	replicate=biological replicate3
PRJNA387092	SRX2833309	0	shanghaihuangxin	leaf	leaves between 0.5 and 1 cm in breadth, folded;	stage 2
PRJNA387092	SRX2833321	0	shanghaihuangxin	leaf	leaves between 2and 2.5 cm in breadth, nearly unfolded, with clear stem exten-sion	stage 5
PRJNA387092	SRX2833323	0.042077	shanghaihuangxin	leaf	leaves >3 cm, unfolded, with clearstem extension	stage 7
PRJNA543957	SRX5879598	0.03517	Zhangzhou lvqing	stem		Se3	100 ppm Na2SeO4
PRJNA543957	SRX5879599	0	Zhangzhou lvqing	stem		Se2	100 ppm Na2SeO4
PRJNA543957	SRX5879600	0	Zhangzhou lvqing	stem		Mock2	mock
PRJNA543957	SRX5879601	0	Zhangzhou lvqing	stem		Mock1	mock
PRJNA543957	SRX5879602	0.060771	Zhangzhou lvqing	stem		Se1	100 ppm Na2SeO4
PRJNA543957	SRX5879603	0.144859	Zhangzhou lvqing	stem		Mock3	mock
PRJNA609149	SRX7815917	0.654383	Jinnan Shiqin	flower bud	early flower bud	early flower bud
PRJNA609149	SRX7815918	1.117694	Jinnan Shiqin	flower bud	middle flower bud	middle flower bud
PRJNA609149	SRX7815919	0.14997	Jinnan Shiqin	flower bud	early flowering period	early flowering period

Network

🔍 Co-expression Network

🔍 Protein-Protein Interaction Network

Orthology

Family	Species	Count	Orthologous Genes
Acanthaceae	Avicennia marina	3	jg18682, jg1869, jg8331
Anacardiaceae	Pistacia vera	1	pistato.v30003640
Apiaceae	Apium graveolens	2	Ag2G02557, AgUnG00499
Solanaceae	Lycium barbarum	5	gene-LOC132613084, gene-LOC132613089, gene-LOC132613094 ... gene-LOC132627290, gene-LOC132642378
Solanaceae	Solanum chilense	5	SOLCI000552200, SOLCI001268300, SOLCI001371800 ... SOLCI006104900, SOLCI006105000
Solanaceae	Solanum pennellii	7	gene-LOC107019742, gene-LOC107032678, gene-LOC107032679 ... gene-LOC107032680, gene-LOC114077215, gene-LOC114077216, gene-LOC114077219